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This step-up dosing method is designed to improve tolerability and reduce the likelihood of gastrointestinal side effects such as nausea or stomach discomfort

First, GLP-1 RA has been shown to have powerful hypoglycemic effects, and the influence of blood glucose on these mechanisms cannot be ruled out

doi:10.4021/JEM.V3I1-2.157 Heffernan M, Summers RJ, Thorburn A, et al

Patients should maintain adequate hydration, especially during the initial weeks when nausea may reduce fluid intake, and continue balanced nutrition despite reduced appetite to ensure adequate protein and micronutrient intake

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